Involvement of extracellular matrix protein matrilin-2 in oval cell-mediated rat liver regeneration
نویسندگان
چکیده
منابع مشابه
The extracellular-matrix protein matrilin 2 participates in peripheral nerve regeneration.
Matrilins are adaptor proteins of the extracellular matrix involved in the formation of both collagen-dependent and collagen-independent filamentous networks. Although their molecular structure and binding partners have been characterized, the functional roles of the four matrilin family members in vivo are still largely unknown. Here, we show that matrilin 2, expressed in pre-myelinating Schwa...
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In case of hepatic damage, the liver uses a unique regeneration mechanism through proliferation of hepatocytes. If this process is inhibited, bipotent oval stem cells proliferate and differentiate to hepatocytes and bile ducts, thus restoring liver mass. Although oval cell accumulation in the liver is often associated with inflammatory processes, the role of lymphocytes in oval cell-mediated he...
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BACKGROUND/AIMS In the 2-acetylaminofluorene (2-AAF)/70% partial hepatectomy (PHx) model, the mechanism underlying the differentiation of activated hepatic oval cells (HOCs) into hepatocytes and bile ductile cells is unclear. We investigated the role of cyclooxygenase-2 (COX-2) in HOCs and the relationship between COX-2 and extracellular matrix proteins in cellular proliferation. METHODS Reve...
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We determined whether the formation of the hepatic primordium in the rat is associated with the expression of liver-specific markers. Fur ther, we examined the origin of intraand extrahepatic bile ducts and tried to establish whether there are cell types in the developing liver that might correspond to "stem-like" cells ("oval cells'1) that proliferate during carcinogenesis and toxic injury in ...
متن کاملCell lineages and oval cell progenitors in rat liver development.
We determined whether the formation of the hepatic primordium in the rat is associated with the expression of liver-specific markers. Further, we examined the origin of intra- and extrahepatic bile ducts and tried to establish whether there are cell types in the developing liver that might correspond to "stem-like" cells ("oval cells") that proliferate during carcinogenesis and toxic injury in ...
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ژورنال
عنوان ژورنال: World Chinese Journal of Digestology
سال: 2010
ISSN: 2219-2859
DOI: 10.11569/wcjd.v18.i4.346